Knecht, Margrith E. and Mayr, Michael and Ferrari, Silvia and Scheiflinger, Friedrich and Trendelenburg, Marten. (2010) A patient with SLE-associated thrombotic microangiopathy and non-neutralizing antibodies against ADAMTS13. Nephrology, dialysis, transplantation, Vol. 25, H. 5. pp. 1720-1722.
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Official URL: http://edoc.unibas.ch/dok/A6003366
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Abstract
In this case report, we describe for the first time a patient with thrombotic thrombocytopaenic purpura (TTP) accompanying highly active systemic lupus erythematosus (SLE) that was associated with non-neutralizing antibodies against the plasma metalloprotease ADAMTS13. Those non-neutralizing antibodies could have been the cause of ADAMTS13 depletion and consecutive TTP. More extensive analyses are required to determine the prevalence as well as the clinical relevance of non-neutralizing antibodies against ADAMTS13 in SLE patients.
| Faculties and Departments: | 03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Clinical Immunology (Trendelenburg) |
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| UniBasel Contributors: | Trendelenburg, Marten |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Oxford University Press |
| ISSN: | 0931-0509 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
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| Last Modified: | 21 Jun 2013 12:29 |
| Deposited On: | 21 Jun 2013 12:25 |
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