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Serotonergic neurotransmission and lapses of attention in children and adolescents with attention deficit hyperactivity disorder : availability of tryptophan influences attentional performance

Zepf, Florian D. and Gaber, Tilman J. and Baurmann, David and Bubenzer, Sarah and Konrad, Kerstin and Herpertz-Dahlmann, Beate and Stadler, Christina and Poustka, Fritz and Wöckel, Lars. (2010) Serotonergic neurotransmission and lapses of attention in children and adolescents with attention deficit hyperactivity disorder : availability of tryptophan influences attentional performance. International journal of neuropsychopharmacology, Vol. 13, H. 7. pp. 933-941.

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Official URL: http://edoc.unibas.ch/dok/A6006944

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Abstract

Deficiencies in serotonergic (5-HT) neurotransmission have frequently been linked to altered attention and memory processes. With attention deficit hyperactivity disorder (ADHD) being associated with impaired attention and working memory, this study investigated the effects of a diminished 5-HT turnover achieved by rapid tryptophan depletion (RTD) on attentional performance in children and adolescents with ADHD. Twenty-two male patients with ADHD (aged 9-15 yr) received the RTD procedure Moja-De and a tryptophan (Trp)-balanced placebo (Pla) in a randomized, double-blind, within-subject crossover design on two separate study days. Lapses of attention (LA) and phasic alertness (PA) were assessed within the test battery for attentional performance under depleted and sham-depleted conditions 120 (T1), 220 (T2) and 300 (T3) min after intake of RTD/Pla. At T1 there was a significant main effect for RTD, indicating more LA under intake of a Trp-balanced Pla compared to diminished 5-HT neurotransmission. For T2/T3 there were no such effects. PA was not affected by the factors RTD/Pla and time. Interactions of 5-HT with other neurotransmitters as possible underlying neurochemical processes could be subject to further investigations involving healthy controls as regards altered attentional performance in children and adolescents.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Kinder- und Jugendpsychiatrie UPK > Kinder- und Jugendpsychiatrische Entwicklungspsychopathologie (Stadler)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Kinder- und Jugendpsychiatrie UPK > Kinder- und Jugendpsychiatrische Entwicklungspsychopathologie (Stadler)
UniBasel Contributors:Stadler, Christina
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Cambridge University Press
ISSN:1461-1457
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:21 Jun 2013 12:29
Deposited On:21 Jun 2013 12:22

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