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Two distinct filopodia populations at the growth cone allow to sense nanotopographical extracellular matrix cues to guide neurite outgrowth

Jang, Kyung-Jin and Kim, Min Sung and Feltrin, Daniel and Jeon, Noo Li and Suh, Kahp-Yang and Pertz, Olivier. (2010) Two distinct filopodia populations at the growth cone allow to sense nanotopographical extracellular matrix cues to guide neurite outgrowth. PLoS ONE, Vol. 5, H. 12 , e15966.

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Official URL: http://edoc.unibas.ch/dok/A6006941

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Abstract

The process of neurite outgrowth is the initial step in producing the neuronal processes that wire the brain. Current models about neurite outgrowth have been derived from classic two-dimensional (2D) cell culture systems, which do not recapitulate the topographical cues that are present in the extracellular matrix (ECM) in vivo. Here, we explore how ECM nanotopography influences neurite outgrowth.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Former Units at DBM > Cell Migration and Neuritogenesis (Pertz)
UniBasel Contributors:Pertz, Olivier
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Public Library of Science
e-ISSN:1932-6203
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:31 Aug 2018 06:40
Deposited On:24 May 2013 09:14

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