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Morphological and functional analysis of the loading regimen with intravitreal ranibizumab in neovascular age-related macular degeneration

Bolz, M. and Simader, C. and Ritter, M. and Ahlers, C. and Benesch, T. and Prünte, C. and Schmidt-Erfurth, U.. (2010) Morphological and functional analysis of the loading regimen with intravitreal ranibizumab in neovascular age-related macular degeneration. British journal of ophthalmology, Vol. 94, no. 2. pp. 185-189.

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Official URL: http://edoc.unibas.ch/dok/A6003944

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Abstract

Aim To quantify and correlate the morphological and functional effects of the recommended loading regimen with intravitreal ranibizumab in neovascular age-related macular degeneration (AMD). Methods In a prospective, interventional clinical trial, 29 consecutive patients (29 eyes) with choroidal neovascularisation secondary to AMD received three initial monthly intravitreal injections of ranibizumab. During this loading regimen, best corrected visual acuity (BCVA) and microperimetry (MP) testing, as well as optical coherence tomography and fluorescein angiography (FA), were performed using a standardised protocol and the results correlated. Results Significant morphological and functional therapeutic effects were observed as early as 1 week following the first treatment. Throughout the loading-dose period, central retinal thickness, including intraretinal cysts and subretinal fluid, decreased fast and significantly (p>0.01); pigment epithelial detachment resolved less rapidly. The mean leakage area by FA decreased (p>0.01) and retinal function (BCVA and MP) increased significantly (both p>0.01). However, the change in morphology and function was only significant between baseline and week 1. There was no significant additional morphological or functional benefit following the second and third injection. Conclusion The initial administration of intravitreal ranibizumab in neovascular AMD induced a significant effect on intra- and subretinal fluid and visual function; subsequent injections had a less pronounced effect. It remains to be determined whether this loading regimen should be mandatory in all patients or if a single dose regimen would lead to a comparable functional and morphological retinal improvement.
Faculties and Departments:03 Faculty of Medicine > Bereich Spezialfächer (Klinik) > Ophthalmologie USB
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Spezialfächer (Klinik) > Ophthalmologie USB
UniBasel Contributors:Prünte, Christian
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Pulman
ISSN:0007-1161
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:24 May 2013 09:22
Deposited On:24 May 2013 09:12

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