Rage, E. and Jacquemin, B. and Nadif, R. and Oryszczyn, M.-P. and Siroux, V. and Aguilera, I. and Kauffmann, F. and Künzli, N.. (2009) Total serum IgE levels are associated with ambient ozone concentration in asthmatic adults. Allergy : european journal of allergy and clinical immunology : official journal of the European Academy of Allergology and Clinical Immunology, 64 (1). pp. 40-46.
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Official URL: http://edoc.unibas.ch/dok/A5843359
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Abstract
BACKGROUND: Effects of air pollution exposure on IgE-mediated response in asthmatics are poorly investigated. The aim was to examine the relationship between air pollution concentrations and total IgE levels in adult asthmatics. METHODS: The present study relates to the 369 asthmatic adults from the French Epidemiological study on Genetics and Environment of Asthma (EGEA), with availability of data on both total serum IgE measurements and air pollution concentrations. Geo-statistical models were performed on 4 x 4 km grids to assess individual outdoor air pollution exposure. Annual outdoor concentrations of ozone (O(3)), nitrogen dioxide (NO(2)), sulphur dioxide (SO(2)), and particulate matter smaller than 10 microm size (PM(10)), and concentrations of summer ozone were assigned to subject's home address. RESULTS: The geometric mean of total IgE was 161 IU/ml and the average of O(3) exposure was 44.9 +/- 9.5 microg/m(3). Ozone concentrations were positively related to total IgE levels and an increase of 10 microg/m(3) of O(3) resulted in an increase of 20.4% (95% CI = 3.0-40.7) in total IgE levels. Adjustment for age, gender, smoking habits and previous life in the countryside did not change the results, and an increase of 19.1% (2.4-38.6) in total IgE was observed with O(3). Negative associations observed between NO(2) and total IgE levels disappeared after including O(3) in the models. Neither SO(2) nor PM(10) were correlated with total IgE levels. CONCLUSIONS: Results suggest that O(3) or related ambient pollutants may up-regulate total IgE levels among asthmatic adults
Faculties and Departments: | 03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Air Pollution and Health (Künzli) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Former Units within Swiss TPH > Air Pollution and Health (Künzli) |
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UniBasel Contributors: | Künzli, Nino |
Item Type: | Article, refereed |
Article Subtype: | Research Article |
Publisher: | Munksgaard |
ISSN: | 0105-4538 |
Note: | Publication type according to Uni Basel Research Database: Journal article |
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Identification Number: |
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Last Modified: | 05 Sep 2018 11:53 |
Deposited On: | 24 May 2013 09:06 |
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