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B cells from HIV-infected patients with primary central nervous system lymphoma display an activated phenotype and have a blunted TNF- response to TLR9 triggering

Audigé, Annette and Schlaepfer, Erika and von Wyl, Viktor and Miller, Regina C. and Vernazza, Pietro and Nadal, David and Speck, Roberto F. and Shcs, . (2010) B cells from HIV-infected patients with primary central nervous system lymphoma display an activated phenotype and have a blunted TNF- response to TLR9 triggering. AIDS Research and Human Retroviruses, Vol. 26, H. 10. pp. 1063-1074.

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Official URL: http://edoc.unibas.ch/dok/A6006798

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Abstract

Each cell in HIV-associated primary central nervous system lymphoma (PCNSL) harbors latent EBV. Notably, the triggering of TLR9, a key event in HIV pathogenesis, also promotes EBV latency and transformation. We hypothesized that because only a minority of HIV-infected patients develops PCNSL, their B cells exhibit aberrant signaling responses to TLR9 triggering. We found higher levels of IL-6, CD80, and CD86 expression at baseline in B cells of those patients than in B cells of matched controls, whereas TNF-a expression was lower. Notably, on TLR9 triggering with CpG 2006, CD80 and TNF- were up-regulated to a lesser extent in B cells of the former than in those of matched controls. The reduced up-regulation of CD80 might be explained by its higher baseline expression resulting in a more blunted response rather than a specific deficit of the signaling response to TLR9 triggering. However, this cannot explain the blunted TNF- response, which warrants further investigation. Finally, since increased IL-6 expression is linked to EBV-associated Hodgkin s lymphoma, the enhanced baseline expression of IL-6 might be important in the pathogenesis of PCNSL in HIV-infected patients.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Division of Medical Microbiology > Transplantation Virology (Hirsch)
UniBasel Contributors:Hirsch, Hans H.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Mary Ann Liebert
ISSN:0889-2229
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:24 May 2013 09:22
Deposited On:24 May 2013 09:05

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