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Atypical presentation of acute myeloid leukemia : cardiac myeloid sarcoma

Rigamonti, Fabio and Beris, P. and Sanchez-Pareja, A. and Meyer, P. and Ashrafpoor, G. and Zaza, S. and Passweg, J. and Chalandon, Y.. (2009) Atypical presentation of acute myeloid leukemia : cardiac myeloid sarcoma. International journal of hematology, Vol. 89. pp. 693-698.

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Official URL: http://edoc.unibas.ch/dok/A6007035

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Abstract

We present the case of a 52-year-old man with a 2-month history of dyspnea, bilateral pleural effusion and cardiomegaly of rapid onset. A cardiac ultrasound showed pericardial effusion with infiltration of the infero-lateral cardiac wall, right auricle and aortic arch by a mass of unknown origin. Despite 1% blast cells in the peripheral blood, 2 bone marrow biopsies were negative for malignancy. Flow cytometry analysis of the blood and immunohistochemistry study of the pleural liquid showed a blast population of CD34+, CD33+, CD13+ and HLA-DR+ cells; a percutaneous cardiac biopsy showed CD34+ cells in the pericardium which led to the diagnosis of extramedullary acute myeloid leukemia (AML). The patient was treated with induction chemotherapy allowing remission, but unfortunately died of septic shock of fungal origin. This case illustrates a rare presentation of cardiac extramedullary AML.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Hämatologie > Hämatologie (Passweg)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Hämatologie > Hämatologie (Passweg)
UniBasel Contributors:Passweg, Jakob R.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Springer
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:24 May 2013 09:22
Deposited On:24 May 2013 09:04

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