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Asymmetric Hydrogenation of α,β-Unsaturated Carboxylic Esters with Chiral Iridium N,P Ligand Complexes

Woodmansee, David H. and Müller, Marc-Andé and Tröndlin , Lars and Hörmann, Esther and Pfaltz, Andreas. (2012) Asymmetric Hydrogenation of α,β-Unsaturated Carboxylic Esters with Chiral Iridium N,P Ligand Complexes. Chemistry - A European Journal, 18 (43). pp. 13780-13786.

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Official URL: http://edoc.unibas.ch/dok/A6083394

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Abstract

Enantioselective conjugate reduction of a wide range of α,β-unsaturated carboxylic esters was achieved using chiral Ir N,P complexes as hydrogenation catalysts. Depending on the substitution pattern of the substrate, different ligands perform best. α,β-Unsaturated carboxylic esters substituted at the α position are less problematic substrates than originally anticipated and in some cases α-substituted substrates actually reacted with higher enantioselectivity than their β-substituted analogues. The resulting saturated esters with a stereogenic center in the α or β position were obtained in high enantiomeric purity.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Synthetische organische Chemie (Pfaltz)
UniBasel Contributors:Pfaltz, Andreas and Hörmann, Esther
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Wiley
ISSN:0947-6539
e-ISSN:1521-3765
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:10 Apr 2017 09:32
Deposited On:24 May 2013 09:03

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