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Use of changes in B-type natriuretic peptides to detect ischemia in selected patients

Staub, Daniel and Jauslin, Daniel and Freidank, Heike and Taegtmeyer, Anne and Breidthardt, Tobias and Zellweger, Michael J. and Mueller-Brand, Jan and Christ, Michael and Mueller, Christian. (2009) Use of changes in B-type natriuretic peptides to detect ischemia in selected patients. International journal of cardiology, Vol. 136. pp. 40-46.

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Official URL: http://edoc.unibas.ch/dok/A6003710

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Abstract

BACKGROUND: There is accumulating evidence that transient exercise-induced ischemia triggers the release of B-type natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP). The aim of this study was to either confirm or refute a previous investigation suggesting that myocardial ischemia can reliably be detected by exercise-induced changes in BNP or NT-proBNP levels in selected patients. METHODS: A total of 139 consecutive patients with normal left ventricular function and normal resting BNP and NT-proBNP levels referred for rest/stress myocardial perfusion single-photon emission computed tomography (SPECT) were analyzed. Levels of BNP and NT-proBNP were determined before and immediately after symptom-limited bicycle ergometry. RESULTS: Inducible myocardial ischemia on perfusion images was detected in 46 patients (33%). Median exercise-induced increases in BNP (DeltaBNP) and NT-proBNP (DeltaNT-proBNP) were similar in patients with and without inducible ischemia (DeltaBNP 12.7 pg/ml vs. 9.4 pg/ml, p=0.109; DeltaNT-proBNP 7 pg/ml vs. 6 pg/ml, p=0.309). The area under the receiver operating characteristic curve for the ability to detect myocardial ischemia was 0.583 (95% CI, 0.479-0.688) for DeltaBNP, and 0.553 (95% CI, 0.450-0.656) for DeltaNT-proBNP. CONCLUSIONS: Exercise-induced changes in BNP and NT-proBNP do not reliably detect myocardial ischemia in selected patients.
Faculties and Departments:03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Labormedizin
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Labormedizin
03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Stationäre innere Medizin (Schifferli)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Stationäre innere Medizin (Schifferli)
03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Kardiologie
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Kardiologie
03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Angiologie (Jäger)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Angiologie (Jäger)
UniBasel Contributors:Müller, Christian and Zellweger, Michael J. and Freidank, Heike and Staub, Daniel
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Excerpta medica
ISSN:0167-5273
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:24 May 2013 09:22
Deposited On:24 May 2013 09:02

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