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Hearing loss and fluctuating hearing levels in X-linked hypophosphataemic osteomalacia

Pantel, G. and Probst, R. and Podvinec, M. and Gürtler, N.. (2009) Hearing loss and fluctuating hearing levels in X-linked hypophosphataemic osteomalacia. Journal of laryngology and otology, Vol. 123. pp. 136-140.

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Official URL: http://edoc.unibas.ch/dok/A6005116

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Abstract

BACKGROUND AND OBJECTIVE: X-linked hypophosphataemic osteomalacia is the most common of the genetically determined forms of osteomalacia. The occurrence of hearing loss in X-linked hypophosphataemic osteomalacia has been known since 1984. However, observations on the progression of such hearing loss, and suggestions regarding possible therapy, have not previously been published. METHODS: Case report of a patient with X-linked hypophosphataemic osteomalacia and hearing loss, with three years' audiological follow up, description of empirical therapy and literature review. RESULTS: The patient presented with fluctuating hearing. An audiogram showed mild to severe sensorineural hearing loss mainly in the low and high frequencies. A temporary improvement of 20-40 dB after steroid therapy was observed. Four weeks later, hearing had deteriorated again, mainly in the low frequencies. After one year of fluctuating hearing levels, stabilisation occurred. CONCLUSIONS: In X-linked hypophosphataemic osteomalacia, hearing loss occurs predominantly in the low and high frequencies. The hearing loss type and progression pattern point to an endolymphatic hydrops as the pathogenetic mechanism. Steroid therapy may be of some benefit.
Faculties and Departments:03 Faculty of Medicine > Bereich Spezialfächer (Klinik) > Ehemalige Einheiten Spezialfächer (Klinik) > Oto-Rhino-Laryngologie AG (Podvinec)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Spezialfächer (Klinik) > Ehemalige Einheiten Spezialfächer (Klinik) > Oto-Rhino-Laryngologie AG (Podvinec)
UniBasel Contributors:Podvinec, Mihael and Gürtler, Nicolas A.L.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Royal Society of Medicine Press
ISSN:0022-2151
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:24 May 2013 09:22
Deposited On:24 May 2013 09:02

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