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Bevacizumab in combination with paclitaxel for HER-2 negative metastatic breast cancer : an economic evaluation

Dedes, Konstantin J. and Matter-Walstra, Klazien and Schwenkglenks, Matthias and Pestalozzi, Bernhard C. and Fink, Daniel and Brauchli, Peter and Szucs, Thomas D.. (2009) Bevacizumab in combination with paclitaxel for HER-2 negative metastatic breast cancer : an economic evaluation. EJC : European journal of cancer, Vol. 45, H. 8. pp. 1397-1406.

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Official URL: http://edoc.unibas.ch/dok/A5844562

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Abstract

The addition of bevacizumab to weekly paclitaxel as primary chemotherapy for HER-2 negative metastatic breast cancer (MBC) prolongs progression-free survival without a substantial increase of toxicity. A Markov cohort simulation was used to follow the clinical course of typical patients with MBC. Information on response rates and major adverse effects was derived, and transition probabilities were estimated, based on the results of the E2100 clinical trial. Direct costs were assessed from the perspective of the Swiss health system. The addition of bevacizumab to weekly paclitaxel is estimated to cost an additional 40,369euro and to yield a gain of 0.22 quality-adjusted life years (QALYs), resulting in an incremental cost-effectiveness ratio of 189,427euro/QALY gained. Probabilistic sensitivity analysis showed that the willingness-to-pay threshold of 60,000euro was never reached. The addition of bevacizumab to paclitaxel in MBC patients is expensive given the clinical benefit in terms of QALYs gained.
Faculties and Departments:03 Faculty of Medicine > Departement Public Health > Pharmazeutische Medizin ECPM > Pharmazeutische Medizin (Szucs)
UniBasel Contributors:Schwenkglenks, Matthias and Matter-Walstra, Klazien Wietske
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Pergamon Press
ISSN:0959-8049
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:24 May 2013 09:21
Deposited On:24 May 2013 09:02

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