edoc

CPEB3 is associated with human episodic memory

Vogler, Christian and Spalek, Klara and Aerni, Amanda and Demougin, Philippe and Müller, Ariane and Huynh, Kim-Dung and Papassotiropoulos, Andreas and de Quervain, Dominique J.-F.. (2009) CPEB3 is associated with human episodic memory. Frontiers in behavioral neuroscience, 3 (4).

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A5257141

Downloads: Statistics Overview

Abstract

Cytoplasmic polyadenylation element-binding (CPEB) proteins are crucial for synaptic plasticity and memory in model organisms. A highly conserved, mammalian-specific short intronic sequence within CPEB3 has been identified as a ribozyme with self-cleavage properties. In humans, the ribozyme sequence is polymorphic and harbors a single nucleotide polymorphism that influences cleavage activity of the ribozyme. Here we show that this variation is related to performance in an episodic memory task and that the effect of the variation depends on the emotional valence of the presented material. Our data suggest a role for human CPEB3 in human episodic memory.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Molekulare Neurowissenschaften (Papassotiropoulos)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Molekulare Neurowissenschaften (Papassotiropoulos)
05 Faculty of Science > Departement Biozentrum > Services Biozentrum > Life Sciences Training Facility (Papassotiropoulos)
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Molecular Psychology (Papassotiropoulos)
UniBasel Contributors:Papassotiropoulos, Andreas and Vogler, Christian and Spalek, Klara and de Quervain, Dominique J.-F. and Demougin, Philippe and Aerni, Amanda and Huynh, Kim-Dung
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:02 Jul 2018 17:33
Deposited On:24 May 2013 09:01

Repository Staff Only: item control page