edoc

Determinants of vaccine immunity in the cohort of human immunodeficiency virus-infected children living in Switzerland

Myers, Catherine and Posfay-Barbe, Klara M. and Aebi, Christoph and Cheseaux, Jean-Jacques and Kind, Christian and Rudin, Christoph and Nadal, David and Siegrist, Claire-Anne. (2009) Determinants of vaccine immunity in the cohort of human immunodeficiency virus-infected children living in Switzerland. Pediatric infectious disease journal, Vol. 28. pp. 996-1001.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A6005792

Downloads: Statistics Overview

Abstract

BACKGROUND: Human immunodeficiency virus (HIV)-infected children are at increased risk of infections caused by vaccine preventable pathogens, and specific immunization recommendations have been issued. METHODS: A prospective national multicenter study assessed how these recommendations are followed in Switzerland and how immunization history correlates with vaccine immunity. RESULTS: Among 87 HIV-infected children (mean age: 11.1 years) followed in the 5 Swiss university hospitals and 1 regional hospital, most (76%) had CD4 T cells <25%, were receiving highly active antiretroviral treatment (79%) and had undetectable viral load (60%). Immunization coverage was lower than in the general population and many lacked serum antibodies to vaccine-preventable pathogens, including measles (54%), varicella (39%), and hepatitis B (65%). The presence of vaccine antibodies correlated most significantly with having an up-to-date immunization history (P>0.05). An up-to-date immunization history was not related to age, immunologic stage, or viremia but to the referral medical center. CONCLUSIONS: All pediatricians in charge of HIV-infected children are urged to identify missing immunizations in this high-risk population.
Faculties and Departments:03 Faculty of Medicine > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB) > P├Ądiatrie (Frey)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB) > P├Ądiatrie (Frey)
UniBasel Contributors:Rudin, Christoph
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Lippincott Williams & Wilkins
ISSN:0891-3668
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:24 May 2013 09:21
Deposited On:24 May 2013 09:01

Repository Staff Only: item control page