Sigel, H. and Song, B. and Blindauer, C. A. and Kapinos, L. E. and Gregávn, F. and Prónayová, N.. (1999) Why is the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine in its diphosphorylated form (PMEApp4–) initially a better substrate for polymerases than (2′-deoxy)adenosine 5′-triphosphate (dATP4–/ATP4–)? Considerations on the mechanism of nucleic acid polymerases. Chemical Communications, 35 (8). pp. 743-744.
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Official URL: http://edoc.unibas.ch/dok/A6083512
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Abstract
The observation that the antivirally active PMEA in its diphosphorylated form (PMEApp4–) is initially a better substrate for polymerases than dATP4– (ATP4–) can be rationalized by (i) the increased basicity of the phosphonyl group (compared to a phosphoryl group) and (ii) the participation of the ether O atom of PMEApp4– in metal ion binding; both effects together favor M2+ binding at the α group and thus its nucleophilic attack.
| Faculties and Departments: | 05 Faculty of Science > Departement Chemie |
|---|---|
| UniBasel Contributors: | Kapinos Schneider, Larisa E. E |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 0022-4936 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 01 Dec 2016 07:56 |
| Deposited On: | 24 May 2013 09:00 |
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