Crespo, J. L. and Hall, M. N.. (2002) Elucidating TOR signaling and rapamycin action : lessons from Saccharomyces cerevisiae. Microbiology and molecular biology reviews, Vol. 66, H. 4. pp. 579-591.
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Official URL: http://edoc.unibas.ch/dok/A5258156
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Abstract
TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. Rapamycin is an immunosuppressive and anticancer drug that acts by inhibiting TOR. The modes of action of TOR and rapamycin are remarkably conserved from S. cerevisiae to humans. The current understanding of TOR and rapamycin is derived largely from studies with S. cerevisiae. In this review, we discuss the contributions made by S. cerevisiae to understanding rapamycin action and TOR function.
| Faculties and Departments: | 05 Faculty of Science > Departement Biozentrum > Growth & Development > Biochemistry (Hall) |
|---|---|
| UniBasel Contributors: | Hall, Michael N. |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | American Society for Microbiology |
| ISSN: | 1092-2172 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Last Modified: | 22 Mar 2012 14:20 |
| Deposited On: | 22 Mar 2012 13:19 |
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