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Patterns of recurrence of early breast cancer according to estrogen receptor status : a therapeutic target for a quarter of a century

Pagani, Olivia and Price, Karen N. and Gelber, Richard D. and Castiglione-Gertsch, Monica and Holmberg, Stig B. and Lindtner, Jurij and Thürlimann, Beat and Collins, John and Fey, Martin F. and Coates, Alan S. and Goldhirsch, Aron. (2009) Patterns of recurrence of early breast cancer according to estrogen receptor status : a therapeutic target for a quarter of a century. Breast cancer research and treatment, Vol. 117. pp. 319-324.

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Official URL: http://edoc.unibas.ch/dok/A6005017

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Abstract

The current therapeutic strategy in breast cancer is to identify a target, such as estrogen receptor (ER) status, for tailoring treatments. We investigated the patterns of recurrence with respect to ER status for patients treated in two randomized trials with 25 years' median follow-up. In the ER-negative subpopulations most breast cancer events occurred within the first 5-7 years after randomization, while in the ER-positive subpopulations breast cancer events were spread through 10 years. In the ER-positive subpopulation, 1 year endocrine treatment alone significantly prolonged disease-free survival (DFS) with no additional benefit observed by adding 1 year of chemotherapy. In the small ER-negative subpopulation chemo-endocrine therapy had a significantly better DFS than endocrine alone or no treatment. Despite small numbers of patients, "old-fashioned" treatments, and competing causes of treatment failure, the value of ER status as a target for response to adjuvant treatment is evident through prolonged follow-up.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Onkologie
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Onkologie
UniBasel Contributors:Thürlimann, Beat
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Springer
ISSN:0167-6806
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:24 May 2013 09:21
Deposited On:24 May 2013 09:00

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