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Reduced serotonergic functioning changes heart rate in ADHD

Zepf, Florian Daniel and Holtmann, M. and Stadler, C. and Wöckel, L. and Poustka, F.. (2009) Reduced serotonergic functioning changes heart rate in ADHD. Journal of neural transmission. Basic neurosciences and genetics, Parkinson's disease and allied conditions, Alzheimer's disease and related disorders, biological psychiatry, Vol. 116. pp. 105-108.

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Official URL: http://edoc.unibas.ch/dok/A6005340

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Abstract

Reduced mean heart rate (HR) was shown to be a biophysiological marker for aggression, which in turn was proven to be related to changed serotonergic neurotransmission. A total of 16 ADHD-diagnosed boys were subjected to rapid tryptophan depletion (RTD) and a placebo in a double-blind within-subject crossover-design. Mean HR was assessed under RTD/placebo. Low impulsive patients behaving aggressively under RTD showed a lowered HR under RTD versus placebo. Diminished 5-HT functioning was associated with lowered HR and aggressive behaviour.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Kinder- und Jugendpsychiatrie UPK > Kinder- und Jugendpsychiatrische Entwicklungspsychopathologie (Stadler)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Kinder- und Jugendpsychiatrie UPK > Kinder- und Jugendpsychiatrische Entwicklungspsychopathologie (Stadler)
UniBasel Contributors:Stadler, Christina
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Springer
ISSN:1435-1463
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:24 May 2013 09:21
Deposited On:24 May 2013 08:59

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