Amrein, Beat and Schmid, Maurus and Collet, Guillaume and Cuniasse, Philippe and Gilardoni, Francois and Seebeck, Florian P. and Ward, Thomas R.. (2012) Identification of two-histidines one-carboxylate binding motifs in proteins amenable to facial coordination to metals. Metallomics, 4 (4). pp. 379-388.
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Official URL: http://edoc.unibas.ch/dok/A6070741
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Abstract
Among natural metalloenzymes, the facial two-histidines one-carboxylate binding motif (FTM) is a widely represented first coordination sphere motif present in the active site of a variety of metalloenzymes. A PDB search revealed a total of 1685 structures bearing such FTMs bound to a metal. Sixty statistically representative FTMs were selected and used as template for the identification of structurally characterized proteins bearing these three amino acids in a propitious environment for binding to a transition metal. This geometrical superposition search, carried out using the STAMPS software, returned 2320 hits. While most consisted of either apo-FTMs or bore strong sequence homology to known FTMs, seven such structures lying within a cavity were identified as novel and viable scaffolds for the creation of artificial metalloenzymes bearing an FTM.
Faculties and Departments: | 05 Faculty of Science > Departement Chemie > Chemie > Bioanorganische Chemie (Ward) |
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UniBasel Contributors: | Ward, Thomas R. R. and Schmid, Maurus and Seebeck, Florian Peter and Amrein, Beat |
Item Type: | Article, refereed |
Article Subtype: | Research Article |
Publisher: | Royal Society of Chemistry |
ISSN: | 1756-5901 |
e-ISSN: | 1756-591X |
Note: | Publication type according to Uni Basel Research Database: Journal article |
Identification Number: |
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Last Modified: | 03 May 2017 09:13 |
Deposited On: | 24 May 2013 08:58 |
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