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Recommendations for the use of cardiac troponin measurement in acute cardiac care

Thygesen, Kristian and Mair, Johannes and Katus, Hugo and Plebani, Mario and Venge, Per and Collinson, Paul and Lindahl, Bertil and Giannitsis, Evangelos and Hasin, Yonathan and Galvani, Marcello and Tubaro, Marco and Alpert, Joseph S. and Biasucci, Luigi M. and Koenig, Wolfgang and Mueller, Christian and Huber, Kurt and Hamm, Christian and Jaffe, Allan S. and Study Group on Biomarkers in Cardiology of the ESC Working Group, . (2010) Recommendations for the use of cardiac troponin measurement in acute cardiac care. European heart journal, Vol. 31,. pp. 2197-2204.

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Official URL: http://edoc.unibas.ch/dok/A6006409

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Abstract

The release of cardiomyocyte components, i.e. biomarkers, into the bloodstream in higher than usual quantities indicates an ongoing pathological process. Thus, detection of elevated concentrations of cardiac biomarkers in blood is a sign of cardiac injury which could be due to supply-demand imbalance, toxic effects, or haemodynamic stress. It is up to the clinician to determine the most probable aetiology, the proper therapeutic measures, and the subsequent risk implied by the process. For this reason, the measurement of biomarkers always must be applied in relation to the clinical context and never in isolation. There are a large number of cardiac biomarkers, but they can be subdivided into four broad categories, those related to necrosis, inflammation, haemodynamic stress, and/or thrombosis. Their usefulness is dependent on the accuracy and reproducibility of the measurements, the discriminatory limits separating pathology from physiology, and their sensitivity and specificity for specific organ damage and/or disease processes. In recent years, cardiac biomarkers have become important adjuncts to the delivery of acute cardiac care. Therefore, the Working Group on Acute Cardiac Care of the European Society of Cardiology established a committee to deal with ongoing and newly developing issues related to cardiac biomarkers. The intention of the group is to outline the principles for the application of various biomarkers by clinicians in the setting of acute cardiac care in a series of expert consensus documents. The first of these will focus on cardiac troponin, a pivotal marker of cardiac injury/necrosis.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Stationäre innere Medizin (Schifferli)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Stationäre innere Medizin (Schifferli)
UniBasel Contributors:Müller, Christian
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Oxford University Press
ISSN:0195-668X
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:26 Apr 2013 07:03
Deposited On:26 Apr 2013 07:01

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