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Testosterone levels in healthy men are related to amygdala reactivity and memory performance

Ackermann, Sandra and Spalek, Klara and Rasch, Björn and Gschwind, Leo and Coynel, David and Fastenrath, Matthias and Papassotiropoulos, Andreas and de Quervain, Dominique J.-F.. (2012) Testosterone levels in healthy men are related to amygdala reactivity and memory performance. Psychoneuroendocrinology, 37 (9). pp. 1417-1424.

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Official URL: http://edoc.unibas.ch/dok/A6002577

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Abstract

Testosterone is a steroid hormone thought to influence both emotional and cognitive functions. It is unknown, however, if testosterone also affects the interaction between these two domains, such as the emotional arousal-induced enhancement of memory. Healthy subjects (N=234) encoded pictures taken from the International Affective Picture System (IAPS) during functional magnetic resonance imaging (fMRI) and underwent a free recall test 10min after memory encoding. We show that higher endogenous testosterone levels at encoding were associated with higher arousal ratings of neutral pictures in men. fMRI analysis revealed that higher testosterone levels were related to increased brain activation in the amygdala during encoding of neutral pictures. Moreover, endogenous testosterone levels were positively correlated with the number of freely recalled neutral pictures. No such relations were found in women. These findings point to a male-specific role for testosterone in enhancing memory by increasing the biological salience of incoming information.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Molekulare Neurowissenschaften (Papassotiropoulos)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Molekulare Neurowissenschaften (Papassotiropoulos)
05 Faculty of Science > Departement Biozentrum > Services Biozentrum > Life Sciences Training Facility (Papassotiropoulos)
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Molecular Psychology (Papassotiropoulos)
UniBasel Contributors:Papassotiropoulos, Andreas and Ackermann, Sandra and Sifalakis, Klara and Gschwind, Leo and Coynel, David and Fastenrath, Matthias and de Quervain, Dominique J.-F.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:0306-4530
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:19 Jun 2018 13:54
Deposited On:26 Apr 2013 06:59

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