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Interleukin-7 links T lymphocyte and intestinal epithelial cell homeostasis

Shalapour, Shabnam and Deiser, Katrin and Kühl, Anja A. and Glauben, Rainer and Krug, Susanne M. and Fischer, André and Sercan, Ozen and Chappaz, Stephane and Bereswill, Stefan and Heimesaat, Markus M. and Loddenkemper, Christoph and Fromm, Michael and Finke, Daniela and Hämmerling, Günter J. and Arnold, Bernd and Siegmund, Britta and Schüler, Thomas. (2012) Interleukin-7 links T lymphocyte and intestinal epithelial cell homeostasis. PLoS ONE, 7 (2). e31939.

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Official URL: http://edoc.unibas.ch/dok/A6005361

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Abstract

Interleukin-7 (IL-7) is a major survival factor for mature T cells. Therefore, the degree of IL-7 availability determines the size of the peripheral T cell pool and regulates T cell homeostasis. Here we provide evidence that IL-7 also regulates the homeostasis of intestinal epithelial cells (IEC), colon function and the composition of the commensal microflora. In the colon of T cell-deficient, lymphopenic mice, IL-7-producing IEC accumulate. IEC hyperplasia can be blocked by IL-7-consuming T cells or the inactivation of the IL-7/IL-7R signaling pathway. However, the blockade of the IL-7/IL-7R signaling pathway renders T cell-deficient mice more sensitive to chemically-induced IEC damage and subsequent colitis. In summary, our data demonstrate that IL-7 promotes IEC hyperplasia under lymphopenic conditions. Under non-lymphopenic conditions, however, T cells consume IL-7 thereby limiting IEC expansion and survival. Hence, the degree of IL-7 availability regulates both, T cell and IEC homeostasis.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Children's Hospital > Developmental Immunology (Finke)
UniBasel Contributors:Finke, Daniela
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Public Library of Science
e-ISSN:1932-6203
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:31 Aug 2018 06:33
Deposited On:26 Apr 2013 06:58

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