Placental microparticles, DNA, and RNA in preeclampsia

Rusterholz, Corinne and Messerli, Marianne and Hoesli, Irene and Hahn, Sinuhe. (2011) Placental microparticles, DNA, and RNA in preeclampsia. Hypertension in pregnancy, Vol. 30, no. 3. pp. 364-375.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A6007447

Downloads: Statistics Overview


Preeclampsia is a common disorder of the second half of pregnancy that complicates 2% to 7% of all pregnancies worldwide and remains a major cause of maternal and fetal morbidity and mortality. Although the origin of the disease is still elusive, population-based studies have suggested that it might implicate genetic, immunologic, or physiologic factors. On the other hand, there is no doubt that the placenta plays an important role in its development. In preeclampsia, the shedding of placenta debris, such as syncytiotrophoblast microparticles (STBMs) and DNA and messenger RNA molecules, into the maternal peripheral blood is increased. The analysis of this material may give new insight into placentation and the underlying etiology of this disorder, as well as yield new tracks of research for the understanding of the molecular mechanisms, leading to the generation of the clinical symptoms.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Prenatal Medicine (Hahn)
03 Faculty of Medicine > Bereich Spezialfächer (Klinik) > Gynäkologie und Geburtshilfe > Geburtshilfe (Hösli-Krais)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Spezialfächer (Klinik) > Gynäkologie und Geburtshilfe > Geburtshilfe (Hösli-Krais)
UniBasel Contributors:Hahn, Sinuhe and Hösli-Krais, Irene M.
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Publisher:Taylor & Francis
Note:Publication type according to Uni Basel Research Database: Journal item
Related URLs:
Identification Number:
Last Modified:08 May 2015 08:45
Deposited On:26 Apr 2013 06:56

Repository Staff Only: item control page