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Optical and molecular techniques to identify tumor margins within the larynx

Hughes, Owain R. and Stone, Nicholas and Kraft, Marcel and Arens, Christoph and Birchall, Martin A.. (2010) Optical and molecular techniques to identify tumor margins within the larynx. Head & neck, Vol. 32, H. 11. pp. 1544-1553.

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Official URL: http://edoc.unibas.ch/dok/A6006819

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Abstract

Failure to remove tumor cells from the larynx significantly increases the risk of local recurrence following surgical excision. Healthy tissue must be preserved to optimize long-term vocal and swallowing function. It is essential to accurately distinguish between healthy mucosa, dysplasia, and invasive carcinoma. Optical and molecular examining technologies have been developed to improve tumor margin identification in vivo. We aimed to review the efficacy of these technologies. Published articles were identified using MEDLINE, EMBASE, and Cochrane central register of controlled trials (CENTRAL). Randomized clinical trials are required to establish the benefit to patients and cost to the health service of using 5-aminolevulinic acid (ALA)-induced fluorescent imaging, contact endoscopy, and optical coherence tomography (OCT). Furthermore, primary research is required to validate other techniques, such as confocal endomicroscopy and Raman spectroscopy, and to develop their clinical applications in the larynx.
Faculties and Departments:03 Faculty of Medicine > Bereich Spezialfächer (Klinik) > Ehemalige Einheiten Spezialfächer (Klinik) > Oto-Rhino-Laryngologie AG (Podvinec)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Spezialfächer (Klinik) > Ehemalige Einheiten Spezialfächer (Klinik) > Oto-Rhino-Laryngologie AG (Podvinec)
UniBasel Contributors:Kraft, Marcel Thomas
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:John Wiley
ISSN:1097-0347
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:24 May 2013 09:14
Deposited On:26 Apr 2013 06:55

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