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EGFR-Mutationsanalyse beim nichtkleinzelligen Lungenkarzinom

Tapia, C. and Savic, S. and Bihl, M. and Rufle, A. and Zlobec, I. and Terracciano, L. and Bubendorf, L.. (2009) EGFR-Mutationsanalyse beim nichtkleinzelligen Lungenkarzinom. Der Pathologe : Pathologie und Klinik : Organ von: Internationale Akademie für Pathologie Deutsche Abteilung e.V. ... [et al.], Vol. 30. pp. 384-392.

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Official URL: http://edoc.unibas.ch/dok/A6004362

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Abstract

BACKGROUND: Some patients with non-small cell lung cancer (NSCLC) respond well to therapy with tyrosine kinase inhibitors (TKI). Somatic mutation of the epidermal growth factor receptor (EGFR) gene is an important predictive marker for TKI response. PATIENTS AND METHODS: We performed EGFR mutation analysis in 307 NSCLC (exon 18-21). The data were analyzed for associations with clinical-pathological parameters. RESULTS: Relevant EGFR mutations were found in 25/307 NSCLC (8.1%; 178 biopsies and 129 cytologies). Most mutations were found in exon 19 (50%) followed by the L858R point mutation in exon 21 (12.5%). EGFR mutations were significantly more common in women than in men (16.8% vs. 2.7%; p>0.001) and in adenocarcinoma than in other carcinoma subtypes (11.4% vs. 3.8%; p=0.017). EGFR mutation was associated with TTF-1 positivity (p>0.041). Almost all (96%) mutated NSCLC were TTF-1 positive. CONCLUSION: In Central Europe, the prevalence of relevant EGFR mutations in NSCLC is >10% of patients with NSCLC. EGFR mutations are more common in women and TTF-1 positive adenocarcinomas. Mutation analysis can be performed both from biopsies and cytologies.
Faculties and Departments:03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Pathologie USB > Stammzellpathologie (Bubendorf)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Pathologie USB > Stammzellpathologie (Bubendorf)
03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Pathologie USB > Molekulare Pathologie (Terracciano)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Pathologie USB > Molekulare Pathologie (Terracciano)
UniBasel Contributors:Terracciano, Luigi M. and Bubendorf, Lukas
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Springer
ISSN:0172-8113
Note:Note: Englischer Titel: EGFR mutation analysis in non-small-cell lung cancer : Experience from routine diagnostics -- Publication type according to Uni Basel Research Database: Journal article
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Last Modified:01 Mar 2013 11:14
Deposited On:01 Mar 2013 11:13

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