Cloning and expression of the essential gene for poly(A) polymerase from S. cerevisiae

Lingner, J. and Kellermann, J. and Keller, W.. (1991) Cloning and expression of the essential gene for poly(A) polymerase from S. cerevisiae. Nature, 354 (6353). pp. 496-498.

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Official URL: http://edoc.unibas.ch/dok/A5257988

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Poly(A) polymerase is essential for the maturation of messenger RNA, adding tracts of adenosine residues to the 3' end of precursor RNA generated by endonucleolytic cleavage. This mechanism of mRNA 3' processing seems to be similar in yeast and in higher eucaryotes, although there are differences in the recognition signals in the pre-mRNA. Here we describe the cloning of the gene for yeast poly(A) polymerase. The enzyme is encoded by a single and essential gene located near the centromere on the left arm of chromosome 11. Poly(A) polymerase purified from recombinant Escherichia coli has the same physical and biochemical properties as the yeast enzyme. The yeast poly(A) polymerase shares features of sequence with its mammalian homologue.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Cell Biology (Keller)
UniBasel Contributors:Keller, Walter
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:07 Nov 2017 14:28
Deposited On:22 Mar 2012 13:19

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