edoc

Molecular crosstalk between a chemical and a biological stressor and consequences on disease manifestation in rainbow trout

Burki, R. and Krasnov, A. and Bettge, K. and Rexroad III, C. E. and Afanasyev, S. and Antikainen, M. and Burkhardt-Holm, P. and Wahli, T. and Segner, H.. (2013) Molecular crosstalk between a chemical and a biological stressor and consequences on disease manifestation in rainbow trout. Aquatic Toxicology, 127. pp. 2-8.

[img] PDF
Restricted to Repository staff only

618Kb

Official URL: http://edoc.unibas.ch/dok/A6070182

Downloads: Statistics Overview

Abstract

The aim of the present study was to examine the molecular and organism reaction of rainbow trout, Oncorhynchus mykiss, to the combined impact of two environmental stressors. The two stressors were the myxozoan parasite, Tetracapsuloides bryosalmonae, which is the etiological agent of proliferative kidney disease (PKD) and a natural stressor to salmonid populations, and 17b-estradiol (E2) as prototype of estrogen-active chemical stressors in the aquatic environment. Both stressors, the parasite and estrogenic contaminants, co-exist in Swiss rivers and are discussed as factors contributing to the decline of Swiss brown trout populations over the last decades. Using a microarray approach contrasting parasite-infected and non-infected rainbow trout at low or high estrogen levels, it was observed that molecular response patterns under joint exposure differed from those to the single stressors. More specifically, three major response patterns were present: (i) Gene expression responses to one stressor are weakened by the presence of the second stressor; (ii) Gene expression responses to one stressor are enhanced by the presence of the second stressor; (iii) Gene expression responses at joint treatment are dominated by one of the two stressors. Organism-level responses to concurrent E2 and parasite treatment – assessed through measuring parasite loads in the fish host and cumulative moralities of trout - were dominated by the pathogen, with no modulating influence of E2. The findings reveal function- and level-specific responses of rainbow trout to stressor combinations, which are only partly predictable from the response to the single stressors.
Faculties and Departments:05 Faculty of Science > Departement Umweltwissenschaften > Mensch Gesellschaft Umwelt MGU > Aquatische Ökologie (Holm)
UniBasel Contributors:Holm, Patricia
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:0166-445X
e-ISSN:1879-1514
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:24 Aug 2018 09:46
Deposited On:01 Feb 2013 08:45

Repository Staff Only: item control page