African Trypanosomes as model system for functional analyses of microbial motility

Engstler, Markus and Heddergott, Niko and Krüger, Tim and Stellamanns, Eric and Uppaluri, Sravanti and Pfohl, Thomas. (2012) African Trypanosomes as model system for functional analyses of microbial motility. In: Nature-Inspired Fluid Mechanics : Results of the DFG Priority Programme 1207 ”Nature-inspired Fluid Mechanics” 2006-2012. Berlin, pp. 43-61.

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The locomotion of microorganisms in a microscopic world, where cells move through a fluid environment without using inertial forces, is a fascinating phenomenon in life science. Nature offers clever and inspiring strategies for self-propelling in an environment of no inertia. The flagellate African trypanosome, which causes African sleeping sickness, moves with help of a flagellum, which is firmly attached to its cell body. The beating flagellum leads to a strong distortion of the cell body and therefore to a swimming agitation of trypanosomes. We have found that trypanosomes use a hydrodynamic mechanism to defend against host’s immune attacks. Owing to continuous and directional swimming, host-derived antibodies attached to surface glycoproteins of the cell are dragged to the posterior cell pole, where they are rapidly internalized and destroyed. In the following we present new methodology and techniques to quantify the movements of proteins and the motility of cells. Moreover trypanosome motility schemes and their influence on cellular lifestyle and survival strategies are characterized.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Former Organization Units Chemistry > Biophysikalische Chemie (Pfohl)
UniBasel Contributors:Pfohl, Thomas
Item Type:Book Section
Book Section Subtype:Further Contribution in a Book
Note:Also published in: Notes on numerical fluid mechanics and multidisciplinary design. - Berlin : Springer. - Vol. 119 (2012), S. 43-61 -- Publication type according to Uni Basel Research Database: Book item
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Last Modified:13 Apr 2018 07:00
Deposited On:01 Feb 2013 08:45

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