edoc

Polymer nanoreactors with dual functionality : simultaneous detoxification of peroxynitrite and oxygen transport

Dobrunz, Dominik and Toma, Adriana C. and Tanner, Pascal and Pfohl, Thomas and Palivan, Cornelia G.. (2012) Polymer nanoreactors with dual functionality : simultaneous detoxification of peroxynitrite and oxygen transport. Langmuir, 28 (45). pp. 15889-15899.

[img] PDF - Published Version
Restricted to Repository staff only

3180Kb

Official URL: http://edoc.unibas.ch/dok/A6070531

Downloads: Statistics Overview

Abstract

The design of multifunctional systems is in focus today as a key strategy for coping with complex challenges in various domains that include chemistry, medicine, environmental sciences, and technology. Herein, we introduce protein-containing polymer nanoreactors with dual functionality: peroxynitrite degradation and oxygen transport. Vesicles made of poly-(2-methyloxazoline)-poly(dimethylsiloxane)-poly(2-methyloxazoline) successfully encapsulated hemoglobin (Hb), which serves as a model protein because of its dual function in oxygen transport and peroxynitrite degradation. By inserting channel proteins, the polymer membranes of vesicles permitted passage of various compounds that served for the assessment of in situ Hb activity. The requisite conformational changes in the protein structure and the change in oxidation states that took place within the confined space of the vesicle cavity demonstrated that Hb preserved its dual functionality: peroxynitrite degradation and oxygen transport. The functionality of our nanoreactor, combined with its simple procedure of production and extensive stability over several months, supports it as a promising system for further medical applications.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Biophysikalische Chemie (Pfohl)
05 Faculty of Science > Departement Chemie > Chemie > Makromolekulare Chemie (Meier)
UniBasel Contributors:Dobrunz, Dominik and Toma, Adriana and Tanner, Pascal and Palivan, Cornelia G and Pfohl, Thomas
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Chemical Society
ISSN:0743-7463
e-ISSN:1520-5827
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:16 Feb 2017 09:56
Deposited On:01 Feb 2013 08:45

Repository Staff Only: item control page