Human internal thoracic arteries from diabetic patients are resistant to endothelial dysfunction

Grapow, Martin T. R. and Reineke, David C. and Kern, Thomas and Müller-Schweinitzer, Else and Carrel, Thierry and Eckstein, Friedrich S.. (2009) Human internal thoracic arteries from diabetic patients are resistant to endothelial dysfunction. Fundamental and clinical pharmacology : FCP, Vol. 23. pp. 567-572.

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Official URL: http://edoc.unibas.ch/dok/A6005927

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The aim of this analysis was to compare vasoreactive properties of internal thoracic arteries (ITA) grafts from diabetic (DM) to those of non-diabetic (ND) patients. Ring segments of ITA, taken from patients undergoing coronary artery bypass grafting, were suspended in organ bath chambers filled with modified Krebs-Henseleit solution and contractile responses to potassium chloride (KCl), noradrenaline (NA), endothelin-1 (ET-l), and endothelium-dependent relaxant responses to acetylcholine (ACH) were recorded isometrically. The receptor-mediated agonists NA and ET-1 stimulated ITA from both groups within similar concentration ranges while ITA from DM patients proved to be significantly more sensitive to KCl than ITA from ND. Furthermore, maximal contractile responses indicated that KCl (3.79 +/- 0.30 g, n = 7 in DM and 2.50 +/- 0.23 g, n = 29 in ND, P > 0.05) evoked significantly higher responses in ITA from DM as compared to the ND control group while both NA and ET-l stimulated ITA from both groups with similar efficacies. Endothelium-dependent relaxant responses to ACH proved to be similar in both groups when expressed as percentages of the pre-existing tone. The present data support the contention that in comparison to ND controls arteries from DM patients are more sensitive to depolarization but endothelial dysfunction is less frequent in human ITA than expected from observations in systemic vascular beds.
Faculties and Departments:03 Faculty of Medicine > Bereich Operative Fächer (Klinik) > Innere Organe > Herzchirurgie (Eckstein)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Operative Fächer (Klinik) > Innere Organe > Herzchirurgie (Eckstein)
UniBasel Contributors:Eckstein, Friedrich Stefan
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Blackwell Science
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:01 Feb 2013 08:46
Deposited On:01 Feb 2013 08:42

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