edoc

Clinical, phenotypic and genetic similarities and disparities between post-transplant and classical Hodgkin lymphomas with respect to therapeutic targets

Adams, Heiner and Campidelli, Cristina and Dirnhofer, Stephan and Pileri, Stefano A. and Tzankov, Alexandar. (2009) Clinical, phenotypic and genetic similarities and disparities between post-transplant and classical Hodgkin lymphomas with respect to therapeutic targets. Expert opinion on therapeutic targets, Vol. 13. pp. 1137-1145.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A6002985

Downloads: Statistics Overview

Abstract

OBJECTIVE: Post-transplant Hodgkin lymphoma (ptHL) is a rare but serious complication. We explored the clinical, phenotypic and genetic similarities and disparities between ptHL and classical Hodgkin lymphoma (cHL) in immunocompetent patients and sought proteins/pathways in ptHL that might have potential as therapeutic targets. RESEARCH DESIGN AND METHODS: Eight ptHL cases in solid organ recipients (mean patient age 36 years; mean duration between organ transplant and onset of ptHL 80 months) were phenotypically and genotypically analyzed and the results were compared with known phenotypic and molecular characteristics of cHL. RESULTS: All ptHL expressed CD15, CD30 and LMP-1 of EBV; the B-cell markers BOB-1, Oct2, CD79a and CD20 were more commonly expressed in ptHL versus cHL (100%, 86%, 50% and 38% in ptHL compared to 6%, 14%, 10% and 33% in cHL, respectively); all ptHL expressed phosphoinositide 3-kinase (PI3K) versus 81% of cHL; 2/6 (33%) ptHL displayed gains at 9p24 that were similar to cHL (32%). The JAK2 downstream pSTAT3 slightly predominated in ptHL versus cHL (60% versus 50%). Clonal immunoglobulin gene rearrangements were found in 2/4 cases. CONCLUSIONS: ptHL and cHL are closely related, but not identical, neoplasms, with the primary differences being the strict association with EBV infection, persistent phenotypic B-cell signature and high expression of PI3K as well as the slightly CD4-depleted but TIA-1/Granzyme B-enriched cellular background composition in ptHL.
Faculties and Departments:03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Pathologie USB > Histopathologie (Dirnhofer)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Pathologie USB > Histopathologie (Dirnhofer)
UniBasel Contributors:Dirnhofer, Stephan and Tzankov, Alexandar
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Informa Healthcare
ISSN:1472-8222
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:01 Feb 2013 08:46
Deposited On:01 Feb 2013 08:42

Repository Staff Only: item control page