Motor circuits in action : specification, connectivity, and function

Arber, Silvia. (2012) Motor circuits in action : specification, connectivity, and function. Neuron, Vol. 74, H. 6. pp. 975-989.

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Official URL: http://edoc.unibas.ch/dok/A6008356

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Mammalian motor behavior is enabled by a hierarchy of interleaved circuit modules constructed by interneurons in the spinal cord, sensory feedback loops, and bilateral communication with supraspinal centers. Neuronal subpopulations are specified through a process of precisely timed neurogenesis, acquisition of transcriptional programs, and migration to spatially confined domains. Developmental and genetic programs instruct stereotyped and highly specific connectivity patterns, binding functionally distinct neuronal subpopulations into motor circuit modules at all hierarchical levels. Recent work demonstrates that spatial organization of motor circuits relates to precise connectivity patterns and that these patterns frequently correlate with specific behavioral functions of motor output. This Review highlights key examples of how developmental specification dictates organization of motor circuit connectivity and thereby controls movement.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Neurobiology > Cell Biology (Arber)
09 Associated Institutions > Friedrich Miescher Institut FMI
UniBasel Contributors:Arber, Silvia
Item Type:Article, refereed
Article Subtype:Book Review
Publisher:Cell Press
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:01 Feb 2013 08:46
Deposited On:01 Feb 2013 08:41

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