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Homeostatic sleep pressure and responses to sustained attention in the suprachiasmatic area

Schmidt, Christina and Collette, Fabienne and Leclercq, Yves and Sterpenich, Virginie and Vandewalle, Gilles and Berthomier, Pierre and Berthomier, Christian and Phillips, Christophe and Tinguely, Gilberte and Darsaud, Annabelle and Gais, Steffen and Schabus, Manuel and Desseilles, Martin and Dang-Vu, Thien Thanh and Salmon, Eric and Balteau, Evelyne and Degueldre, Christian and Luxen, André and Maquet, Pierre and Cajochen, Christian and Peigneux, Philippe. (2009) Homeostatic sleep pressure and responses to sustained attention in the suprachiasmatic area. Science, Vol. 324. pp. 516-519.

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Official URL: http://edoc.unibas.ch/dok/A6003947

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Abstract

Throughout the day, cognitive performance is under the combined influence of circadian processes and homeostatic sleep pressure. Some people perform best in the morning, whereas others are more alert in the evening. These chronotypes provide a unique way to study the effects of sleep-wake regulation on the cerebral mechanisms supporting cognition. Using functional magnetic resonance imaging in extreme chronotypes, we found that maintaining attention in the evening was associated with higher activity in evening than morning chronotypes in a region of the locus coeruleus and in a suprachiasmatic area (SCA) including the circadian master clock. Activity in the SCA decreased with increasing homeostatic sleep pressure. This result shows the direct influence of the homeostatic and circadian interaction on the neural activity underpinning human behavior.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Klinische Stress- und Traumaforschung (Holsboer-Trachsler)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Klinische Stress- und Traumaforschung (Holsboer-Trachsler)
UniBasel Contributors:Cajochen, Christian
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:American Association for the Advancement of Science
ISSN:0036-8075
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:01 Feb 2013 08:46
Deposited On:01 Feb 2013 08:40

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