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Gastrointestinal neuromuscular pathology : guidelines for histological techniques and reporting on behalf of the Gastro 2009 International Working Group

Knowles, Charles H. and De Giorgio, Roberto and Kapur, Raj P. and Bruder, Elisabeth and Farrugia, Gianrico and Geboes, Karel and Gershon, Michael D. and Hutson, John and Lindberg, Greger and Martin, Joanne E. and Meier-Ruge, William A. and Milla, Peter J. and Smith, Virpi V. and Vandervinden, Jean Marie and Veress, Béla and Wedel, Thilo. (2009) Gastrointestinal neuromuscular pathology : guidelines for histological techniques and reporting on behalf of the Gastro 2009 International Working Group. Acta neuropathologica, Vol. 118. pp. 271-301.

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Official URL: http://edoc.unibas.ch/dok/A6006914

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Abstract

The term gastrointestinal neuromuscular disease describes a clinically heterogeneous group of disorders of children and adults in which symptoms are presumed or proven to arise as a result of neuromuscular, including interstitial cell of Cajal, dysfunction. Such disorders commonly have impaired motor activity, i.e. slowed or obstructed transit with radiological evidence of transient or persistent visceral dilatation. Whilst sensorimotor abnormalities have been demonstrated by a variety of methods in these conditions, standards for histopathological reporting remain relatively neglected. Significant differences in methodologies and expertise continue to confound the reliable delineation of normality and specificity of particular pathological changes for disease. Such issues require urgent clarification to standardize acquisition and handling of tissue specimens, interpretation of findings and make informed decisions on risk-benefit of full-thickness tissue biopsy of bowel or other diagnostic procedures. Such information will also allow increased certainty of diagnosis, facilitating factual discussion between patients and caregivers, as well as giving prognostic and therapeutic information. The following report, produced by an international working group, using established consensus methodology, presents proposed guidelines on histological techniques and reporting for adult and paediatric gastrointestinal neuromuscular pathology. The report addresses the main areas of histopathological practice as confronted by the pathologist, including suction rectal biopsy and full-thickness tissue obtained with diagnostic or therapeutic intent. For each, indications, safe acquisition of tissue, histological techniques, reporting and referral recommendations are presented.
Faculties and Departments:03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Pathologie USB
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Pathologie USB
UniBasel Contributors:Bruder, Elisabeth
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Springer
ISSN:0001-6322
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:01 Feb 2013 08:46
Deposited On:01 Feb 2013 08:40

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