Seizure-induced neuronal death is suppressed in the absence of the endogenous lectin Galectin-1

Bischoff, Vincent and Deogracias, Rubén and Poirier, Françoise and Barde, Yves-Alain. (2012) Seizure-induced neuronal death is suppressed in the absence of the endogenous lectin Galectin-1. Journal of Neuroscience, 32 (44). pp. 15590-15600.

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Official URL: http://edoc.unibas.ch/dok/A6018464

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Pilocarpine injection induces epileptic seizures in rodents, an experimental paradigm extensively used to model temporal lobe epilepsy in humans. It includes conspicuous neuronal death in the forebrain and previous work has demonstrated an involvement of the neurotrophin receptor p75NTR in this process. Following the identification of Galectin-1 (Gal-1) as a downstream effector of p75NTR, we examine here the role of this endogenous lectin in pilocarpine-induced cell death in adult mice. We found that most somatostatin-positive neurons also express Gal-1 and that in mice lacking the corresponding gene Lgals1, pilocarpine-induced neuronal death was essentially abolished. We also found that the related lectin Galectin-3 (Gal-3) was strongly up-regulated by pilocarpine in microglial cells. This up-regulation was absent in Lgals1 mutants and our results with Lgals3 null animals show that Gal-3 is not required for neuronal death. These findings provide new insights into the roles and regulation of endogenous lectins in the adult CNS and a surprisingly selective pro-apoptotic role of Gal-1 for a sub-population of GABAergic interneurons.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Pharmacology/Neurobiology (Barde)
UniBasel Contributors:Barde, Yves-Alain and Deogracias Pastor, Ruben
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Society for Neuroscience
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:27 Nov 2017 13:40
Deposited On:04 Jan 2013 08:37

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