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Pharmacovigilance of drug allergy and hypersensitivity using the ENDA-DAHD database and the GALEN platform : the Galenda project

Bousquet, P.-J. and Demoly, P. and Romano, A. and Aberer, W. and Bircher, A. and Blanca, M. and Brockow, K. and Pichler, W. and Torres, M. J. and Terreehorst, I. and Arnoux, B. and Atanaskovic-Markovic, M. and Barbaud, A. and Bijl, A. and Bonadonna, P. and Burney, P. G. and Caimmi, S. and Canonica, G. W. and Cernadas, J. and Dahlen, B. and Daures, J.-P. and Fernandez, J. and Gomes, E. and Gueant, J.-L. and Kowalski, M. L. and Kvedariene, V. and Mertes, P.-M. and Martins, P. and Nizankowska-Mogilnicka, E. and Papadopoulos, N. and Ponvert, C. and Pirmohamed, M. and Ring, J. and Salapatas, M. and Sanz, M. L. and Szczeklik, A. and Van Ganse, E. and De Weck, A. L. and Zuberbier, T. and Merk, H. F. and Sachs, B. and Sidoroff, A.. (2009) Pharmacovigilance of drug allergy and hypersensitivity using the ENDA-DAHD database and the GALEN platform : the Galenda project. Allergy : european journal of allergy and clinical immunology : official journal of the European Academy of Allergology and Clinical Immunology, Vol. 64. pp. 194-203.

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Official URL: http://edoc.unibas.ch/dok/A6003922

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Abstract

Nonallergic hypersensitivity and allergic reactions are part of the many different types of adverse drug reactions (ADRs). Databases exist for the collection of ADRs. Spontaneous reporting makes up the core data-generating system of pharmacovigilance, but there is a large under-estimation of allergy/hypersensitivity drug reactions. A specific database is therefore required for drug allergy and hypersensitivity using standard operating procedures (SOPs), as the diagnosis of drug allergy/hypersensitivity is difficult and current pharmacovigilance algorithms are insufficient. Although difficult, the diagnosis of drug allergy/hypersensitivity has been standardized by the European Network for Drug Allergy (ENDA) under the aegis of the European Academy of Allergology and Clinical Immunology and SOPs have been published. Based on ENDA and Global Allergy and Asthma European Network (GA(2)LEN, EU Framework Programme 6) SOPs, a Drug Allergy and Hypersensitivity Database (DAHD((R))) has been established under FileMaker((R)) Pro 9. It is already available online in many different languages and can be accessed using a personal login. GA(2)LEN is a European network of 27 partners (16 countries) and 59 collaborating centres (26 countries), which can coordinate and implement the DAHD across Europe. The GA(2)LEN-ENDA-DAHD platform interacting with a pharmacovigilance network appears to be of great interest for the reporting of allergy/hypersensitivity ADRs in conjunction with other pharmacovigilance instruments.
Faculties and Departments:03 Faculty of Medicine > Bereich Spezialfächer (Klinik) > Dermatologie USB > Dermatologie (Bircher)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Spezialfächer (Klinik) > Dermatologie USB > Dermatologie (Bircher)
UniBasel Contributors:Bircher, Andreas J.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Munksgaard
ISSN:0105-4538
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:04 Jan 2013 08:38
Deposited On:04 Jan 2013 08:37

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