Short-term dietary restriction and fasting precondition against ischemia reperfusion injury in mice

Mitchell, James R. and Verweij, Mariëlle and Brand, Karl and van de Ven, Marieke and Goemaere, Natascha and van den Engel, Sandra and Chu, Timothy and Forrer, Flavio and Müller, Cristina and de Jong, Marion and van IJcken, Wilfred and IJzermans, Jan N. M. and Hoeijmakers, Jan H. J. and de Bruin, Ron W. F.. (2010) Short-term dietary restriction and fasting precondition against ischemia reperfusion injury in mice. Aging cell, Vol. 9 H. 1. pp. 40-53.

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Official URL: http://edoc.unibas.ch/dok/A6004919

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Dietary restriction (DR) extends lifespan and increases resistance to multiple forms of stress, including ischemia reperfusion injury to the brain and heart in rodents. While maximal effects on lifespan require long-term restriction, the kinetics of onset of benefits against acute stress is not known. Here, we show that 2-4 weeks of 30% DR improved survival and kidney function following renal ischemia reperfusion injury in mice. Brief periods of water-only fasting were similarly effective at protecting against ischemic damage. Significant protection occurred within 1 day, persisted for several days beyond the fasting period and extended to another organ, the liver. Protection by both short-term DR and fasting correlated with improved insulin sensitivity, increased expression of markers of antioxidant defense and reduced expression of markers of inflammation and insulin/insulin-like growth factor-1 signaling. Unbiased transcriptional profiling of kidneys from mice subject to short-term DR or fasting revealed a significant enrichment of signature genes of long-term DR. These data demonstrate that brief periods of reduced food intake, including short-term daily restriction and fasting, can increase resistance to ischemia reperfusion injury in rodents and suggest a rapid onset of benefits of DR in mammals.
Faculties and Departments:03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Radiologie USB > Nuklearmedizin (Wild)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Radiologie USB > Nuklearmedizin (Wild)
UniBasel Contributors:Forrer, Flavio
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:07 Dec 2012 13:04
Deposited On:07 Dec 2012 13:03

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