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Oxidized phospholipids regulate expression of ATF4 and VEGF in endothelial cells via NRF2-dependent mechanism : novel point of convergence between electrophilic and unfolded protein stress pathways

Afonyushkin, Taras and Oskolkova, Olga V. and Philippova, Maria and Resink, Therese J. and Erne, Paul and Binder, Bernd R. and Bochkov, Valery N.. (2010) Oxidized phospholipids regulate expression of ATF4 and VEGF in endothelial cells via NRF2-dependent mechanism : novel point of convergence between electrophilic and unfolded protein stress pathways. Arteriosclerosis, thrombosis, and vascular biology, Vol. 30, H. 5. pp. 1007-1013.

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Official URL: http://edoc.unibas.ch/dok/A6004303

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Abstract

The ATF4 arm of the unfolded protein response is increasingly recognized for its relevance to pathology, and in particular to angiogenic reactions. Oxidized phospholipids (OxPLs), known to accumulate in atherosclerotic vessels, were shown to upregulate vascular endothelial growth factor (VEGF) and induce angiogenesis via an ATF4-dependent mechanism. In this study, we analyzed the mechanism of ATF4 upregulation by OxPLs and more specifically the involvement of NRF2, the major transcriptional mediator of electrophilic stress response.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Further Research Groups at DBM > Signal Transduction (Resink/Erne)
UniBasel Contributors:Resink, Thérèse J. and Erne, Paul
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:American Heart Association
ISSN:1079-5642
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:07 Dec 2012 13:04
Deposited On:07 Dec 2012 13:02

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