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Cell-based therapy for myocardial repair in patients with acute myocardial infarction : rationale and study design of the SWiss multicenter Intracoronary Stem cells Study in Acute Myocardial Infarction (SWISS-AMI)

Sürder, Daniel and Schwitter, Jürg and Moccetti, Tiziano and Astori, Giuseppe and Rufibach, Kaspar and Plein, Sven and Lo Cicero, Viviana and Soncin, Sabrina and Windecker, Stephan and Moschovitis, Aris and Wahl, Andreas and Erne, Paul and Jamshidi, Peiman and Auf der Maur, Christoph and Manka, Robert and Soldati, Gianni and Bühler, Ines and Wyss, Christophe and Landmesser, Ulf and Lüscher, Thomas F. and Corti, Roberto. (2010) Cell-based therapy for myocardial repair in patients with acute myocardial infarction : rationale and study design of the SWiss multicenter Intracoronary Stem cells Study in Acute Myocardial Infarction (SWISS-AMI). American heart journal, Vol. 160, H. 1. pp. 58-64.

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Official URL: http://edoc.unibas.ch/dok/A6006424

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Abstract

Recent studies report that intracoronary administration of autologous bone marrow mononucleated cells (BM-MNCs) may improve remodeling of the left ventricle after acute myocardial infarction (AMI). Subgroup analysis suggest that early treatment between days 4 and 7 after AMI is probably most effective; however, the optimal time point of intracoronary cell administration has never been addressed in clinical trials. Furthermore, reliable clinical predictors are lacking for identifying patients who are thought to have most benefit from cellular therapy.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Further Research Groups at DBM > Signal Transduction (Resink/Erne)
UniBasel Contributors:Erne, Paul
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:C.V. Mosby
ISSN:0002-8703
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:07 Dec 2012 13:04
Deposited On:07 Dec 2012 13:02

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