Reticulon 3 is involved in membrane trafficking between the endoplasmic reticulum and Golgi

Wakana, Y. and Koyama, S. and Nakajima, K. and Hatsuzawa, K. and Nagahama, M. and Tani, K. and Hauri, H. -P. and Melancon, P. and Tagaya, M.. (2005) Reticulon 3 is involved in membrane trafficking between the endoplasmic reticulum and Golgi. Biochemical and biophysical research communications, Vol. 334, H. 4. pp. 1198-1205.

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Official URL: http://edoc.unibas.ch/dok/A5257746

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Reticulons (RTNs) constitute a family of endoplasmic reticulum (ER)-associated proteins with a reticular distribution. Despite the implication of their neuronal isoforms in axonal regeneration, the function of their widely expressed isoforms is largely unknown. In this study, we examined the role of the ubiquitously expressed RTN3 in membrane trafficking. Ectopically expressed RTN3 exhibited heterogeneous patterns; filamentous, reticular, and granular distributions. The ER morphology changed accordingly. In cells where RTN3 displayed a filamentous/reticular distribution, protein transport between the ER and Golgi was blocked, and Golgi proteins were dispersed. In contrast, ERGIC-53, a marker for the ER-Golgi intermediate compartment, accumulated at the perinuclear region, and remained there even after cells were treated with agents that induce redistribution of Golgi proteins to the ER, indicating an inhibition of Golgi-to-ER transport of ERGIC-53. These results suggest that RTN3 plays a role in membrane trafficking in the early secretory pathway.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Pharmacology/Neurobiology (Hauri)
UniBasel Contributors:Hauri, Hans-Peter
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:18 Jul 2014 09:10
Deposited On:22 Mar 2012 13:18

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