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The physiological period length of the human circadian clock in vivo is directly proportional to period in human fibroblasts

Pagani, Lucia and Semenova, Ekaterina A. and Moriggi, Ermanno and Revell, Victoria L. and Hack, Lisa M. and Lockley, Steven W. and Arendt, Josephine and Skene, Debra J. and Meier, Fides and Izakovic, Jan and Wirz-Justice, Anna and Cajochen, Christian and Sergeeva, Oksana J. and Cheresiz, Sergei V. and Danilenko, Konstantin V. and Eckert, Anne and Brown, Steven A.. (2010) The physiological period length of the human circadian clock in vivo is directly proportional to period in human fibroblasts. PLoS ONE, Vol. 5, H. 10 , e13376.

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Official URL: http://edoc.unibas.ch/dok/A6005129

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Abstract

Diurnal behavior in humans is governed by the period length of a circadian clock in the suprachiasmatic nuclei of the brain hypothalamus. Nevertheless, the cell-intrinsic mechanism of this clock is present in most cells of the body. We have shown previously that for individuals of extreme chronotype ("larks" and "owls"), clock properties measured in human fibroblasts correlated with extreme diurnal behavior.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Erwachsenenpsychiatrie (Lang)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Erwachsenenpsychiatrie (Lang)
03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Klinische Stress- und Traumaforschung (Holsboer-Trachsler)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Klinische Stress- und Traumaforschung (Holsboer-Trachsler)
UniBasel Contributors:Cajochen, Christian and Eckert, Anne
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Public Library of Science
e-ISSN:1932-6203
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:31 Aug 2018 06:40
Deposited On:07 Dec 2012 13:00

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