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A small number of open Ca2+ channels trigger transmitter release at a central GABAergic synapse

Bucurenciu, Iancu and Bischofberger, Josef and Jonas, Peter. (2010) A small number of open Ca2+ channels trigger transmitter release at a central GABAergic synapse. Nature neuroscience, Vol. 13, H. 1. pp. 19-21.

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Official URL: http://edoc.unibas.ch/dok/A6003857

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Abstract

To determine the number of open Ca(2+) channels necessary for transmitter release at the inhibitory basket cell-granule cell synapse in rat hippocampus, we combined presynaptic Ca(2+) imaging, recording of postsynaptic currents and modeling. We found that that the opening of three or fewer Ca(2+) channels triggered transmitter release. Furthermore, a small number of Ca(2+) channels were able to evoke release with high temporal precision, despite stochastic Ca(2+) channel opening.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Division of Physiology > Cellular Neurophysiology (Bischofberger)
UniBasel Contributors:Bischofberger, Josef
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Nature America
ISSN:1097-6256
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 Nov 2012 16:23
Deposited On:08 Nov 2012 16:19

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