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Assessment of the photo-degradation of UV-filters and radical-induced peroxidation in cosmetic sunscreen formulations

Damiani, Elisabetta and Astolfi, Paola and Giesinger, Jochen and Ehlis, Thomas and Herzog, Bernd and Greci, Lucedio and Baschong, Werner. (2010) Assessment of the photo-degradation of UV-filters and radical-induced peroxidation in cosmetic sunscreen formulations. Free radical research, Vol. 44, H. 3. pp. 304-312.

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Official URL: http://edoc.unibas.ch/dok/A6005682

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Abstract

Photo-instability of common UV-filters is a well documented phenomenon. This study develops a method for concomitant measurement of photostability and photo-induced ROS generation in cosmetic formulations. Oil-in-water formulations containing three common UV filters (OMC, BMDBM, EHT), individually or combined, were further supplemented with phosphatidylcholine and exposed to UVA. All filters show spectral decrease after UVA exposure. OMC and EHT do not induce significant lipid-peroxidation (as measured by TBARS production) while BMDBM does. In the latter case, this is reduced when BMDBM is combined with OMC but not with EHT. Neither OMC nor EHT stabilize BMDBM with respect to loss of absorbance. ROS-generation assessed via TBARS formation was supported by EPR experiments. The UV-induced changes in UV-filter performance, as monitored in the model formulations and in commercial sunscreens, demonstrate that this is a simple and effective method for stability assessment of sunscreen filters under conditions of use.
Faculties and Departments:03 Faculty of Medicine > Departement Zahnmedizin > Klinik Zahnärztliche Chirurgie > Kieferchirurgie (Lambrecht)
UniBasel Contributors:Baschong, Werner
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Harwood Academic Publishers
ISSN:1071-5762
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 Nov 2012 16:23
Deposited On:08 Nov 2012 16:18

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