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Changes of the hepatic proteome in hepatitis B-infected mouse model at early stages of fibrosis

Spano, D. and Cimmino, F. and Capasso, M. and D'Angelo, F. and Zambrano, N. and Terracciano, L. and Iolascon, A.. (2008) Changes of the hepatic proteome in hepatitis B-infected mouse model at early stages of fibrosis. Journal of Proteome Research, Vol. 7, H. 7. pp. 2642-2653.

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Official URL: http://edoc.unibas.ch/dok/A6006641

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Abstract

Liver fibrosis (LF) is the accumulation of extracellular matrix (ECM) proteins due to chronic liver injury. We used two-dimensional differential in-gel electrophoresis (2D-DIGE) to perform a comparative analysis of cytosolic and nuclear protein patterns of nontransgenic (NTg) and HBV transgenic (Tg) mice livers at early stages of fibrosis. We identified several candidate proteins, involved in a variety of pathways, which could be used as putative biomarkers for LF early detection.
Faculties and Departments:03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Pathologie USB > Molekulare Pathologie (Terracciano)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Pathologie USB > Molekulare Pathologie (Terracciano)
UniBasel Contributors:Terracciano, Luigi M.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:American Chemical Society
ISSN:1535-3893
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 Nov 2012 16:23
Deposited On:08 Nov 2012 16:18

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