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Polyomavirus BK replication dynamics in vivo and in silico to predict cytopathology and viral clearance in kidney transplants

Funk, G. A. and Gosert, R. and Comoli, P. and Ginevri, F. and Hirsch, H. H.. (2008) Polyomavirus BK replication dynamics in vivo and in silico to predict cytopathology and viral clearance in kidney transplants. American journal of transplantation, Vol. 8. pp. 2368-2377.

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Official URL: http://edoc.unibas.ch/dok/A6004863

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Abstract

Fast BK virus (BKV) replication in renal tubular epithelial cells drives polyomavirus-BK-associated nephropathy (PVAN) to premature kidney transplant (KT) failure. BKV also replicates in urothelial cells, but remains asymptomatic in two-thirds of affected KT patients. Comparing 518 day-matched plasma-urine samples from 223 KT patients, BKV loads were approximately 3000-fold higher in urine than in plasma (p 95% of urine BKV loads resulted from urothelial replication and 80% was required for clearing viremia within 7 weeks, but viruria persisted for <14 weeks. Reductions <90% cleared viremia and viruria by 3 and 10 weeks, respectively. The model was clinically validated in prospectively monitored KT patients supporting <80% curtailing for optimal interventions.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Division of Medical Microbiology > Transplantation Virology (Hirsch)
UniBasel Contributors:Gosert, Rainer and Hirsch, Hans H.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Munksgaard
ISSN:1600-6135
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 Nov 2012 16:22
Deposited On:08 Nov 2012 16:14

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