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Dynamic formation of oriented patches in chondrocyte cell cultures

Grote, M. J. and Palumberi, V. and Wagner, B. and Barbero, A. and Martin, I.. (2011) Dynamic formation of oriented patches in chondrocyte cell cultures. Journal of mathematical biology, Vol. 63, H. 4. pp. 757-777.

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Official URL: http://edoc.unibas.ch/dok/A6005878

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Abstract

Growth factors have a significant impact not only on the growth dynamics but also on the phenotype of chondrocytes (Barbero et al. in J. Cell. Phys. 204:830-838, 2005). In particular, as chondrocytes approach confluence, the cells tend to align and form coherent patches. Starting from a mathematical model for fibroblast populations at equilibrium (Mogilner et al. in Physica D 89:346-367, 1996), a dynamic continuum model with logistic growth is developed. Both linear stability analysis and numerical solutions of the time-dependent nonlinear integro-partial differential equation are used to identify the key parameters that lead to pattern formation in the model. The numerical results are compared quantitatively to experimental data by extracting statistical information on orientation, density and patch size through Gabor filters.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Cell and Gene Therapy (Banfi)
03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Tissue Engineering (Martin)
05 Faculty of Science > Departement Mathematik und Informatik > Mathematik > Numerik (Grote)
UniBasel Contributors:Barbero, Andrea and Grote, Marcus J. and Martin, Ivan
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Springer
ISSN:1432-1416
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 May 2015 08:44
Deposited On:08 Nov 2012 16:11

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