Horseradish Peroxidase as a Catalyst for Atom Transfer Radical Polymerization

Sigg, Severin J. and Seidi, Farzad and Renggli, Kasper and Silva, Tilana B. and Kali, Gergely and Bruns, Nico. (2011) Horseradish Peroxidase as a Catalyst for Atom Transfer Radical Polymerization. Macromolecular rapid communications, Vol. 32, H. 21. pp. 1710-1715.

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Official URL: http://edoc.unibas.ch/dok/A6002608

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The hemoprotein horseradish peroxidase (HRP) catalyzes the polymn. of N-isopropylacrylamide with an alkyl bromide initiator under conditions of activators regenerated by electron transfer atom transfer radical polymn. (ARGET ATRP) in the absence of any peroxide. This is a novel activity of HRP, which we propose to name ATRPase activity. Bromine-terminated polymers with polydispersity indexes (PDIs) as low as 1.44 are obtained. The polymn. follows first order kinetics, but the evolution of mol. wt. and the PDI upon increasing conversion deviate from the results expected for an ATRP mechanism. Conversion, ?Mn and PDI depend on the pH and on the concn. of the reducing agent, sodium ascorbate. HRP is stable during the polymn. and does not unfold or form conjugates.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie
05 Faculty of Science > Departement Chemie > Chemie > Makromolekulare Chemie (Meier)
UniBasel Contributors:Bruns, Nico
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:11 Oct 2012 15:32
Deposited On:11 Oct 2012 15:25

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