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A genome-wide survey and functional brain imaging study identify CTNNBL1 as a memory-related gene

Papassotiropoulos, A. and Stefanova, E. and Vogler, C. and Gschwind, L. and Ackermann, S. and Spalek, K. and Rasch, B. and Heck, A. and Aerni, A. and Hanser, E. and Demougin, P. and Huynh, K.-D. and Luechinger, R. and Klarhöfer, M. and Novakovic, I. and Kostic, V. and Boesiger, P. and Scheffler, K. and de Quervain, D. J.-F.. (2013) A genome-wide survey and functional brain imaging study identify CTNNBL1 as a memory-related gene. Molecular psychiatry, Vol. 18, H. 2. S. 255-263.

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Official URL: http://edoc.unibas.ch/dok/A6001933

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Abstract

Unbiased genome-wide screens combined with imaging data on brain function may identify novel molecular pathways related to human cognition. Here we performed a dense genome-wide screen to identify episodic memory-related gene variants. A genomic locus encoding the brain-expressed beta-catenin-like protein 1 (CTNNBL1) was significantly (P=7 × 10(-8)) associated with verbal memory performance in a cognitively healthy cohort from Switzerland (n=1073) and was replicated in a second cohort from Serbia (n=524; P=0.003). Gene expression studies showed CTNNBL1 genotype-dependent differences in beta-catenin-like protein 1 mRNA levels in the human cortex. Functional magnetic resonance imaging in 322 subjects detected CTNNBL1 genotype-dependent differences in memory-related brain activations. Converging evidence from independent experiments and different methodological approaches suggests a role for CTNNBL1 in human memory.Molecular Psychiatry advance online publication, 22 November 2011; doi:10.1038/mp.2011.148.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Kognitive Neurowissenschaften (de Quervain)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Kognitive Neurowissenschaften (de Quervain)
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Molecular Psychology (Papassotiropoulos)
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Cognitive Neuroscience (de Quervain)
UniBasel Contributors:Vogler, Christian and Papassotiropoulos, Andreas and Gschwind, Leo and Ackermann, Sandra and Sifalakis, Klara and Rasch, Björn and Heck, Angela and Aerni, Amanda and Hanser, Edveena and Demougin, Philippe and Scheffler, Klaus and de Quervain, Dominique J.-F.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Nature Publishing Group
ISSN:1359-4184
Note:Note: Online erschienen: 22.11.2011 -- Note: Korrigendum auf S. 264 -- Publication type according to Uni Basel Research Database: Journal article
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Last Modified:07 Nov 2014 08:29
Deposited On:11 Oct 2012 15:23

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