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Proteome analysis in cardiovascular pathophysiology using Dahl rat model

Grussenmeyer, T. and Meili-Butz, S. and Roth, V. and Dieterle, T. and Brink, M. and Winkler, B. and Matt, P. and Carrel, T. P. and Eckstein, F. S. and Lefkovits, I. and Grapow, M. T.. (2011) Proteome analysis in cardiovascular pathophysiology using Dahl rat model. Journal of proteomics, Vol. 74, H. 5. pp. 672-682.

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Official URL: http://edoc.unibas.ch/dok/A6004664

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Abstract

Dahl salt-sensitive (DS) and salt-resistant (DR) inbred rat strains represent a well established animal model for cardiovascular research. Upon prolonged administration of high-salt-containing diet, DS rats develop systemic hypertension, and as a consequence they develop left ventricular hypertrophy, followed by heart failure. The aim of this work was to explore whether this animal model is suitable to identify biomarkers that characterize defined stages of cardiac pathophysiological conditions. The work had to be performed in two stages: in the first part proteomic differences that are attributable to the two separate rat lines (DS and DR) had to be established, and in the second part the process of development of heart failure due to feeding the rats with high-salt-containing diet has to be monitored. This work describes the results of the first stage, with the outcome of protein expression profiles of left ventricular tissues of DS and DR rats kept under low salt diet. Substantial extent of quantitative and qualitative expression differences between both strains of Dahl rats in heart tissue was detected. Using Principal Component Analysis, Linear Discriminant Analysis and other statistical means we have established sets of differentially expressed proteins, candidates for further molecular analysis of the heart failure mechanisms.
Faculties and Departments:03 Faculty of Medicine > Bereich Operative Fächer (Klinik) > Innere Organe > Herzchirurgie (Eckstein)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Operative Fächer (Klinik) > Innere Organe > Herzchirurgie (Eckstein)
03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Allgemeine innere Medizin USB > Ambulante innere Medizin (Hess C)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Allgemeine innere Medizin USB > Ambulante innere Medizin (Hess C)
05 Faculty of Science > Departement Mathematik und Informatik > Informatik > Datenanalyse (Roth)
03 Faculty of Medicine > Departement Biomedizin > Division of Physiology > CardioBiology (Brink)
UniBasel Contributors:Eckstein, Friedrich Stefan and Eckstein, Friedrich and Dieterle, Thomas and Brink, Marijke and Roth, Volker
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:1874-3919
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:10 Apr 2015 09:13
Deposited On:11 Oct 2012 15:23

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