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Regulation of TOR by small GTPases

Durán, R. V. and Hall, M. N.. (2012) Regulation of TOR by small GTPases. EMBO Reports, 13 (2). pp. 121-128.

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Abstract

TOR is a conserved serine/threonine kinase that responds to nutrients, growth factors, the bioenergetic status of the cell and cellular stress to control growth, metabolism and ageing. A diverse group of small GTPases including Rheb, Rag, Rac1, RalA and Ryh1 play a variety of roles in the regulation of TOR. For example, while Rheb binds to and activates TOR directly, Rag and Rac1 regulate its localization and RalA activates it indirectly through the production of phosphatidic acid. Here, we review recent findings on the regulation of TOR by small GTPases.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Biochemistry (Hall)
UniBasel Contributors:Hall, Michael N.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Nature Publishing Group
ISSN:1469-221X
e-ISSN:1469-3178
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:05 Oct 2017 09:53
Deposited On:11 Oct 2012 15:19

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