Interaction of phospholipids with Ca2+ ions : On the role of the phospholipid head groups

Seelig, J.. (1990) Interaction of phospholipids with Ca2+ ions : On the role of the phospholipid head groups. Cell Biology International Reports, 14 (4). pp. 353-360.

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Official URL: http://edoc.unibas.ch/dok/A5257477

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Neutral phospholipids play an important role in Ca2+ binding to biomembranes, in particular if the membrane carries a net negative surface charge due to charged lipids or proteins. The concentration of Ca2+ ions in the plane of the phospholipid head groups can be enhanced by at least two orders of magnitude compared to bulk solution. Ca2+ binding furthermore changes the orientation of the phospholipid head groups which is accompanied by variations of the local membrane dipole potential of the order of 10(5) V/cm. Such high electric fields could entail conformational changes of membrane-bound proteins and the Ca2(+)-induced reorientation of the lipid dipoles could thus play a regulatory role in membrane function.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Biophysical Chemistry (Seelig J)
UniBasel Contributors:Seelig, Joachim
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Academic Press
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:14 Nov 2017 12:31
Deposited On:22 Mar 2012 13:18

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